The Binding of Isaac: Afterbirth+

What's your 'never again' item combo?

Which two items together have genuinely ruined a run for you? Synergies that sound good but absolutely aren't.

Best room layout you've seen?

Ever walk into a room and immediately think 'whoever designed this knew what they were doing'? Describe the layout that impressed you.

Which character feels completely different now?

Pick a character and explain how your strategy for them has changed since you got better at the game.